Expression of cyclins in ductal hyperplasia, atypical ductal hyperplasia and ductal carcinomain situof the breast
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چکیده
منابع مشابه
Ductal Epithelial Lesions: Ductal Carcinoma In Situ vs Atypical Ductal Hyperplasia vs Flat Epithelial Atypia
Before the era of mammography, ductal carcinoma in situ (DCIS) comprised only less than 3% of newly diagnosed breast cancers, most as large palpable masses, and many with microscopic foci of invasion. With widespread use of mammography, DCIS now makes up about 25% of breast cancers diagnosed in the U.S., most as non-palpable lesions. There is also concurrent increased prevalence of atypical duc...
متن کاملP63 and cytokeratin8/18 expression in breast, atypical ductal hyperplasia, ductal carcinoma in situ and invasive duct carcinoma.
Background and Purpose : The pattern and distribution of p63 expression as a myoepithelial/basal stem cell marker can be different between atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) and may denote basal phenotype of breast ductal carcinoma. CK8/18 is a luminal marker and may indicate a luminal phenotype of IDC and its expression in ADH...
متن کاملBorderline atypical ductal hyperplasia/low-grade ductal carcinoma in situ on breast needle core biopsy should be managed conservatively.
The differential diagnosis of low-nuclear grade intraductal epithelial proliferations of the breast includes atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). This distinction can be difficult on core needle biopsy (CNB) but can have significant clinical ramifications. We examined the clinical course of patients diagnosed on CNB with borderline ADH/DCIS lesions [marked ADH ...
متن کاملGenetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization.
PURPOSE Breast cancer is thought to develop from noninvasive precursor lesions, although the earliest steps of neoplastic transformation are still undefined. Usual ductal hyperplasia (UDH) is considered to represent a benign proliferation of ductal epithelial cells, whereas atypical ductal hyperplasia (ADH) may represent the first clonal neoplastic expansion of these cells. The aim of this stud...
متن کاملThe Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia
Signal Transducer and Activation of Transcription factors (STAT3 and STAT5) play important roles in breast epithelial cell differentiation, proliferation, and apoptosis. They have been investigated extensively in established breast cancer, but their activation status in precancerous lesions has not been reported. Formalin-fixed, paraffin-embedded archival tissues from 59 cases of atypical ducta...
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ژورنال
عنوان ژورنال: Yonsei Medical Journal
سال: 2000
ISSN: 0513-5796
DOI: 10.3349/ymj.2000.41.3.345